A Dual-Stage Pseudo-Labeling Method for the Diagnosis of Mental Disorder on MRI Scans

The high prevalence of mental disorders gradually poses a huge pressure on the public healthcare services. Recently, deep learning-based computer-aided diagnosis has been introduced to relieve the tension in healthcare institutions by automatically detecting abnormal neuroimaging-derived pheno-types in patients. However, the training of deep learning models relies on sufficiently large annotated datasets, which can be costly, time-consuming, and laborious. Semi-supervised learning (SSL) can mitigate this challenge by leveraging both labeled and unlabeled samples. In this work, an effective dual-stage pseudo-labeling based classification framework dubbed DSPL is proposed to diagnose mental disorders on functional magnetic resonance imaging data. A bicriteria-based pseudo-labels selection method is developed to filter out inferior pseudo-labeled samples. Subsequently, we further propose a self-mutual learning enhanced pseudo-labeling generation approach to mitigate the adverse effects bought by the noisy pseudo-labeled samples. On real-world datasets, the proposed method achieves diagnosis accuracies of 68.09%, 67.94%, and 68.13% on ABIDE-I, ABIDE-II, and ADHD-200, respectively. Ablation study suggests that each component in DSPL makes a great contribution to performance improvement.